Teratogenicity, mutagenicity, and cellular toxicity of phthalate esters.
نویسندگان
چکیده
منابع مشابه
Teratogenicity, mutagenicity, and cellular toxicity of phthalate esters.
Growing concern that phthalic acid esters (PAE) may present a health hazard and possible deleterious effects on the ecological system has led to increased interest in the more subtle toxicity of those compounds. Although the acute toxicity of PAEs as a group is quite low, the intrinsic cellular toxicity increases with molecular weight. Whether the intrinsic toxicity is great enough to exert a s...
متن کاملAssessment of the mutagenicity of phthalate esters.
The Ames assay was used to investigate the mutagenicity of several phthalate esters as an approximation of their carcinogenic potential. The ortho diesters, dimethyl phthalate (DMP) and diethyl phthalate (DEP) produced a positive dose-related mutagenic response with Salmonella TA100, but only in the absence of S-9 liver enzymes. Dibutyl, di(2-ethylhexyl), mono(2-ethylhexyl), and butyl benzyl ph...
متن کاملMitochondrial toxicity of phthalate esters.
The effects of mono- and dibutyl phthalate and mono- and di(2-ethylhexyl) phthalate on energy-dependent K+ uptake, respiration rates, and succinate cytochrome c reductase activities of isolated rat liver mitochondria were evaluated. The energy-coupling processes, active K+ transport and oxidative phosphorylation, were affected most by di-n-butyl phthalate and mono(2-ethylhexyl) phthalate. Mono-...
متن کاملAspects of the testicular toxicity of phthalate esters.
Di(2-ethylhexyl) phthalate (DEHP) produced seminiferous tubular atrophy and reductions in seminal vesicle and prostate weight in 4-week-old, but not in 15-week-old rats. Di-n-pentyl phthalate (DPP) did produce atrophy in the older rats but this developed more slowly than in young animals. Coadministration of testosterone or gonadotrophins did not protect against phthalate-induced testicular tox...
متن کاملExposure to phthalate esters.
The American Chemistry Council Phthalate Esters Panel read with great interest the paper by Blount et al. (1) regarding urinary levels of phthalate ester metabolites in a sample set of the Third National Health and Nutrition Examination Survey (NHANES III) population. We have known for some time of this research, and have provided whatever information and assistance we could to the Centers for ...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1973
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.730381